In 1911 the second floor of the building became the office of the White Lake Land Company. This group of developers conducted business at this location until the construction of their own offices in the building now known as the Florence Hunting Club.

Later, the Southern Bell Telephone Company occupied the second floor of the bank. Gueydan had one of the first dial telephone systems in the state. The telephone company moved to its own building before the flood of 1940.

In succeeding years, several dentists, family doctors, the Gueydan Library and the Masonic Lodge were located above the bank. In 1966, the Bank of Gueydan moved to its new building across Main Street. The first floor of the old bank building was later used for law offices, Art & Craft Shows and the St. Peter's Care Center.

The building was sold to the Masons in 1980 for the intended purpose of renovating it for their Lodge. They later decided to construct a new building. In 1989, the Gueydan Museum and Cultural Arts Society spearheaded a community fundraising campaign to purchase this historic building. One year later, on August 16, 1990, the deed was transferred. On that day, the former Bank of Gueydan building began its new life as Gueydan's future museum.